Killer Instinct is a series of fighting video games originally created by Rare and published by Midway, Nintendo, and Microsoft Studios. The original Killer Instinct was released for arcades in 1994; the game was then released for the Super NES and Game Boy in 1995. Its popularity led to a sequel, Killer Instinct 2, which was released for arcades in 1996; the game was then released as Killer Instinct Gold for the Nintendo 64.

The series was rebooted with the release of Killer Instinct (2013) for the Xbox One.